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A VDR is a useful tool to have if you encounter situations where external parties require access to confidential information. For instance, if lawyers counsel auditors, accountants, or legal counsel need to access documents belonging to the company, the leadership team must find an option to allow them access without putting the information at risk of being stolen or hacked. A VDR can be beneficial in these instances since it permits documents to be shared with outside parties, while maintaining strict security measures.
The genome-wide actions of VDR depend on its binding to 1,25(OH2)2D3 which encourages dimerization and allows binding to Vitamin D Response Elements (VDRE) within vitamin D target genes. VDR cannot bind to most VDRE within the genome in the absence of RXR. This leads to very little direct impact on the genome. To further understand the genomic actions of VDR, future studies must determine the precise locations where ligand binding to RXR and VDRE facilitates binding to DNA regulatory regions and the molecular mechanisms used by they regulate gene expression.
In the naive T cells, antigen-specific triggering of T cell receptors (TCR) causes intracellular signaling events that promote upregulation of VDR. This upregulation is required for T cells that are naive to respond to peptide and steroid signals and to trigger adaptive immune responses. The DNA regulatory elements cis-acting which are required for VDR activation have not yet been identified however it is likely that they will be involved in direct interaction with the P38 kinase.
